Leo Howard as Nathan Drake
Cillian Murphy as Richard Drake
Rebecca Hall as Cassandra Drake
Dylan O'Brain as Peter Parker
Tye Sheridan as Harry Osborn
Dacre Montgomery as Flash Thompson
Sophie Turner as Mary Jane Watson
Anya Taylor-Joy as Gwen Stacy
Boyd Holbrook as Scorpion
Anthony Ramos as Shocker
Jason Isaacs as Norman Osborn
Samuel L Jackson as Nick Fury
Jensan Ackles as Hydroman
Adam Driver as Dr. Michael Morbius
Rudy Pankow as Johnny Storm
John Krasinski as Reed Richards
Emily Blunt as Sue Storm
Liev Schreiber as Ben Grimm
Kyle Chandler as George Stacy
Mark Ruffalo as Ben Parker
Marisa Tomei as May Parker
Chris Evens as Steve Rogers
Pedro Pascal as Tony Stark
Dan Stevens as Hank Pym
Nicholas Hoult as Justin Hammer
Ashley Greene as Janet van Dyne
Scarlett Johansson as Natasha Romanoff
Matthias Schoenaerts as Crimson Dynamo